I wrote an article on Blizzard Watch that measures the impact of extra movement on Fel Beam, being targeted by the Orb of Destruction, having a mediocre legendary, and more.
The full article is here: Climbing the Ranks: Ranged on Krosus
Super cool and nerdy sim craft!
FWIW, affliction locks in particular usually have the option to do most of the running while we refresh our dots between drain cycles.
We’ll need 2-3 instant cast refreshes, meaning a min of 2 full GCDs, plenty of time to do the full run with no stutter step required. just do it first chance you get after the most recent beam.