First of all let me say that I absolutely love the option to have multiple setups per character optimized to interact with each other based on priority. I used to do this by hand before and it was a serious headache to manage. I play about 16 120 toons and most of the specs for all of them (at least I have gear sets for most all of the specs) so it was a really daunting task that the multiple setups option all but eliminates.
I do have one request though. My main toon is a Druid (4specs) so the number of setups that we can have is more restrictive on him than on the other toons. This is what I setup for gearsets (and yes I use all of them at one point or another)
Guardian: Raid Progression set, Raid Farm set, Raid “all Defense” set, Mythic+ set
Balance: Raid(single target), Mythic+ (AOE)
Feral: Raid(single target), Mythic+ (AOE)
Resto: Raid healing, Mythic+ Healing
So with the current restriction on the number of setups that we can have it leaves me 3 setups short to hit all of my sets. I manage right now by just running all of my guardian builds and my 3 raid setups for the other specs, and then running it again with all of my guardian builds and swapping the other 3 to my M+ setups. The problem is that there are Azerite gear conflicts that I always have to manage my way through.