You should run it again when you get a new legendary item, if you plan to switch to that item. Run the gearing strategy with the two legendary items you plan to use.
The 52nd point doesn’t matter that much. Some of the other points that change the damage distributions of your abilities would matter more.
Otherwise run it again about every 10 item levels you gain.
Forgot the disclaimer that once we finish our “version 2” gearing strategies for ToS, you shouldn’t need custom strategies at all. We will let everyone know when that happens.